Table of contents Abbreviations .............................................................................................................................8

Preface........................................................................................................................................10

Chapter 1. General prescription...................................................................................11

1.1. Dosed medicinal forms.................................................................................................12

One-answer tests.............................................................................................................12

Tasks on prescribing of dosed medicinal forms....................................................16

1.2. Non-dosed medicinal forms........................................................................................17

One-answer tests.............................................................................................................17

Tasks on prescribing of non-dosed medicinal forms..........................................21

Chapter 2. General pharmacology ..............................................................................23

2.1. Pharmacokinetics............................................................................................................25

One-answer tests.............................................................................................................25

Cases....................................................................................................................................29

Instruction to the experimental work .......................................................................32

2.2. Pharmacodynamics........................................................................................................32

One-answer tests.............................................................................................................32

Cases....................................................................................................................................37

Instruction to the experimental work .......................................................................40

Chapter 3. Drugs influencing afferent innervation.............................................41

3.1. Drugs inhibiting afferent innervation......................................................................43

One-answer tests.............................................................................................................43

Cases....................................................................................................................................47

Instruction to the experimental work .......................................................................50

3.2. Drugs stimulating afferent innervation................................................................... 51

One-answer tests.............................................................................................................51

Cases....................................................................................................................................55

Instruction to the experimental work .......................................................................58

Chapter 4. Autonomics......................................................................................................59

4.1. Cholinergic agonists.......................................................................................................60

One-answer tests.............................................................................................................60

Cases....................................................................................................................................64

Instruction to the experimental work .......................................................................67

4.2. Cholinergic antagonists................................................................................................67

One-answer tests.............................................................................................................67

Cases....................................................................................................................................72

Instruction to the experimental work .......................................................................74 

4.3. Adrenergic agonists.......................................................................................................75

One-answer tests.............................................................................................................75

Cases....................................................................................................................................80

Instruction to the experimental work .......................................................................82

4.4. Adrenergic antagonists.................................................................................................83

One-answer tests.............................................................................................................83

Cases....................................................................................................................................88

Instruction to the experimental work .......................................................................90

4.5. Histaminergic and serotoninergic drugs................................................................91

One-answer tests.............................................................................................................91

Cases....................................................................................................................................95

Chapter 5. CNS inhibitors.................................................................................................99

5.1. General anesthetics. Ethyl alcohol ..........................................................................100

One-answer tests...........................................................................................................100

Cases..................................................................................................................................104

Instruction to the experimental work .....................................................................107

5.2. Opioid (narcotic) analgesics......................................................................................108

One-answer tests...........................................................................................................108

Cases..................................................................................................................................112

5.3. Non-opioid (non-narcotic) analgesics...................................................................115

One-answer tests...........................................................................................................115

Cases..................................................................................................................................120

Instruction to the experimental work .....................................................................122

5.4. Hypnotics, antiepileptics, antiparkinsonian drugs............................................123

One-answer tests...........................................................................................................123

Cases..................................................................................................................................128

Instruction to the experimental work .....................................................................131

Chapter 6. Psychoactive drugs....................................................................................132

6.1. Neuroleptics, anxiolytics, sedatives, lithium salts..............................................133

One-answer tests...........................................................................................................133

Cases..................................................................................................................................137

Instruction to the experimental work .....................................................................140

Chapter 7. CNS stimulants.............................................................................................144

7.1. Antidepressants.............................................................................................................145

One-answer tests...........................................................................................................145

Cases..................................................................................................................................149 

7.2. Psychomotor stimulants and analeptics...............................................................152

One-answer tests...........................................................................................................152

Cases..................................................................................................................................157

Instruction to the experimental work .....................................................................159

7.3. Nootropics, adaptogens, anorexigens...................................................................160

One-answer tests...........................................................................................................160

Cases..................................................................................................................................164

Chapter 8. Cardiovascular drugs................................................................................168

8.1. Inotropic drugs...............................................................................................................169

One-answer tests...........................................................................................................169

Cases..................................................................................................................................173

Instruction to the experimental work .....................................................................176

8.2. Antianginal drugs..........................................................................................................176

One-answer tests...........................................................................................................176

Cases..................................................................................................................................181

Instruction to the experimental work .....................................................................184

8.3. Antiarrhythmic drugs...................................................................................................185

One-answer tests...........................................................................................................185

Cases..................................................................................................................................189

8.4. Antihypertensive drugs. Hypertensive preparations.......................................192

One-answer tests...........................................................................................................192

Cases..................................................................................................................................196

8.5. Anti-atherosclerotic drugs.........................................................................................199

One-answer tests...........................................................................................................199

Cases..................................................................................................................................204

Chapter 9. Drugs acting on blood system..............................................................207

9.1. Drugs acting on blood coagulation and fibrinolysis........................................208

One-answer tests...........................................................................................................208

Cases..................................................................................................................................212

Instruction to the experimental work .....................................................................215

9.2. Hematinics. Drugs acting on erythropoiesis.......................................................215

One-answer tests...........................................................................................................215

Cases..................................................................................................................................220

9.3. Drugs acting on leukopoiesis and immunity. Anticancer drugs..................223

One-answer tests...........................................................................................................223

Cases..................................................................................................................................228

Chapter 10. Drugs acting on other effector organs ..........................................231

10.1. Drugs acting on respiration ....................................................................................232

One-answer tests...........................................................................................................232

Cases..................................................................................................................................236

10.2. Drugs acting on digestion system........................................................................239

One-answer tests...........................................................................................................239

Cases..................................................................................................................................244

Instruction to the experimental work .....................................................................246

10.3. Drugs acting on kidneys (diuretics). Antigout drugs.....................................247

One-answer tests...........................................................................................................247

Cases..................................................................................................................................252

Instruction to the experimental work .....................................................................254

10.4. Drugs acting on myometrium................................................................................255

One-answer tests...........................................................................................................255

Cases..................................................................................................................................259

Chapter 11. Drugs acting on metabolism ..............................................................263

11.1. Hormonal preparations of peptide structure...................................................264

One-answer tests...........................................................................................................264

Cases..................................................................................................................................268

Instruction to the experimental work .....................................................................271

11.2. Hormonal preparations of steroidal structure .................................................272

One-answer tests...........................................................................................................272

Cases..................................................................................................................................276

Instruction to the experimental work .....................................................................279

11.3. Vitamin preparations.................................................................................................279

One-answer tests...........................................................................................................279

Cases..................................................................................................................................284

Instruction to the experimental work .....................................................................287

11.4. Enzymes and anti-enzymes. ..................................................................................287

One-answer tests...........................................................................................................287

Cases..................................................................................................................................292

Instruction to experimental work.............................................................................294

Chapter 12. Antimicrobials. Antivirals. Antiparasitic drugs..........................295

12.1. Antiseptics and disinfectants.................................................................................296

One-answer tests...........................................................................................................296

Cases..................................................................................................................................300

Instruction to the experimental work .....................................................................303  

12.2. Antibiotics – cell wall synthesis inhibitors.........................................................303

One-answer tests...........................................................................................................303

Cases..................................................................................................................................308

12.3. Antibiotics – protein synthesis inhibitors. ........................................................311

One-answer tests...........................................................................................................311

Cases..................................................................................................................................315

Instruction to the experimental work .....................................................................318

12.4. Sulfonamides. Synthetic antimicrobials of different structure. Antifungals...........................................................................318

One-answer tests...........................................................................................................318

Cases..................................................................................................................................323

Instruction to the experimental work .....................................................................326

12.5. Antispirochetal and antimycobacterial drugs. Antiviral preparations....326

One-answer tests...........................................................................................................326

Cases..................................................................................................................................331

12.6. Antiprotozoals..............................................................................................................334

One-answer tests...........................................................................................................334

Cases..................................................................................................................................338

Instruction to the experimental work .....................................................................341

12.7. Antihelminthics...........................................................................................................342

One-answer tests...........................................................................................................342

Cases..................................................................................................................................346

Instruction to the experimental work .....................................................................349

Chapter 13 Pharmacotherapy of acute poisonings. Antidotes................................................................................350

One-answer tests...........................................................................................................351

Cases..................................................................................................................................355

Instruction to the experimental work .....................................................................358

Answers....................................................................................................................................359

Selected references.............................................................................................................366