Зміст книги 

Abbreviations

Preface

Introduction (MD, PhD, DSc, Professor Nikolay N. Zayko)

The Subject and Tasks of Pathological Physiology

Relationship Between Pathological Physiology and Other Medical Sciences, Its Importance for Clinical Disciplines

Experiment as the Basic Method of Pathological Physiology

Historical Sketch of the Development of Pathological Physiology (MD, PhD, DSc, Professor Valentin F. Myslitskiy; MD, PhD, DSc, Professor Sergey V. Ziablitsev)

PART ONE. GENERAL NOSOLOGY

Chapter I. General Theory of Diseases (MD, PhD, DSc, Professor Nikolay N. Zayko)

Health

Disease

Principles of Diseases Classification

Pathological Reaction, Pathological Process, Pathological Condition

Typical Pathological Processes

Main Periods (Stages) of Disease Development

Chapter II. Etiology and Pathogenesis (MD, PhD, DSc, Professor  Nikolay N. Zayko)

Etiology

Conditions of the Disease Occurrence

Pathogenesis

The Cause-and-Effect Relationship

General and Local

Structure and Function

Nonspecific and Specific

Adaptation and Compensation

Reactivity and its Role in Pathology (MD, PhD, DSc, Professor Liudmila Ya. Danilova)

Types of Resistance. Relations with Reactivity

Chapter III. Pathogenic Effect of Environmental Factors on the Organism (MD, PhD, Associate Professor  Natalia K. Simeonova)

Mechanical Trauma

Thermal Trauma

Barotrauma

Radiation Injury

Etiology

Pathogenesis

Acute Radiation Disease

Chronic Radiation Disease

Electrotrauma

Pathogenic Effect of Space Flight Factors

Chapter IV. The Role of Heredity, Constitution And Age in Pathology (MD, PhD, Associate Professor  Natalia K. Simeonova)

Genetically Determined Diseases

Classification

Etiology

Pathogenesis

Molecular Genetic (Hereditary) Diseases

Chromosomal Diseases

Hereditary Predisposition

Genetic Examination of a Patient

Principles of Prevention and Treatment of Hereditary Diseases

Role of The Constitution in Pathology

Pathological Physiology of Fetal Development (MD, PhD, DSc, Professor Larisa A. Popova)

Ageing (MD, PhD, DSc, Professor Gennadiy M. Butenko)

Changes in the Body during Aging

Ageing and Diseases

Causes and Mechanisms of Ageing

The Ways of Influence on Ageing

PART TWO. GENERAL PATHOPHYSIOLOGY OF CELLS. TYPICAL METABOLIC DISORDERS

Chapter V. Pathophysiology of Cell (MD, PhD, DSc, Professor Gennadiy M. Butenko)

Disturbances of Cells Functions

Disorders of Metabolic Processes and Environment Interaction

Disturbance of Cell Energy Supply

Disturbances of Genetic Information Storage and Transfer

Intracellular Synthesis Disorders

Dissimilation Interruption

Cell Damage and Death

Chapter VI. Pathology of Energy Balance (MD, PhD, DSc, Professor Liudmila Ya. Danilova; MD, PhD, DSc, Professor Nikolay V. Krishtal)

Chapter  VII. Pathophysiology of Carbohydrate Metabolism (MD, PhD, DSc, Professor Liudmila Ya. Danilova; MD, PhD, DSc, Professor Nikolay V. Krishtal)

Carbohydrate Metabolism and its Regulation

Pathology of the Carbohydrate Metabolism

Chapter VIII. Pathophysiology of Lipid Metabolism (MD, PhD, DSc, Professor Nikolay V. Krishtal; MD, PhD, DSc, Professor Liudmila Ya. Danilova)

Malabsorption of Lipids

Disorders of Lipid Transport and Deposition

Lipid Infiltration and Lipid Dystrophy

Disorder of Intermediate Lipid Metabolism

Disorders of Lipid Metabolism in The Adipose Tissue

Obesity

Weight Loss

Lipidoses

Chapter IX. Pathophysiology of Protein Metabolism (MD, PhD, DSc, Professor Larisa A. Popova; MD, PhD, DSc, Professor Victor Ye. Dosenko)

Disorders of Amino Acid Metabolism

Hereditary Disorders of Metabolism of Certain Amino Acids

Disorders of Final Stages of Protein Metabolism

Disorders of Proteins of the Blood

Disorders of the Nucleic Acids Metabolism

Chapter X. Patophysiology of Acid-Base Homeostasis (MD, PhD, DSc, Professor Nikolay V. Krishtal)

Etiology, Pathogenesis and Forms of Acid-Base Imbalance

The Relationship between ABH and Mineral Exchange

Etiology and Classification of Non-Respiratory Acid-Base Imbalance

Pathological Effects of Acid-Base Imbalance on the Body

Mechanisms of Compensation of Acid-Base Imbalance

Chapter XI. Patophysiology of Water-Electrolyte Balance (MD, PhD, DSc, Professor Nikolay V. Krishtal; MD, PhD, DSc, Professor Oleg I. Sukmanskiy)

Types, Causes, and Consequences of Water-Electrolyte Imbalance

Electrolyte Imbalance

The Exchange of Sodium and Its Imbalance

The Exchange of Potassium and Its Imbalance

The Exchange of Magnesium and Its Imbalance

The Exchange of Chlorine and Its Imbalance

The Exchange of Calcium and Its Imbalance

The Exchange of Phosphorus and Its Imbalance

The Osteoporosis

Chapter XII. Pathophysiology of Microelements Metabolism (MD, PhD, DSc, Professor Nikolay V. Krishtal)

Iron Exchange and Imbalance

Copper Exchange and Imbalance

Zinc Exchange and Imbalance

Manganese Exchange And Imbalance

Chromium Exchange and Imbalance

Vanadium Exchange and Imbalance

Molybdenum Exchange and Imbalance

Selenium Exchange and Imbalance

Iodine Exchange And Imbalance

Fluoride Exchange and Imbalance

Chapter XIII. Pathophysiology of Vitamins Metabolism (MD, PhD, DSc, Professor Nikolay V. Krishtal)

Classification and General Characteristics of Vitamins in the Human Body

Sources of Vitamins and Their Metabolism in the Body

Main Causes of Vitamin Deficiency Development

Deficiency of Antineurotic Vitamin В1

Deficiency of Riboflavin

Deficiency of Antipellagric Vitamin РР

Deficiency of Antidermatitic Vitamin В6

Deficiency of Folic Acid

Deficiency of Antianemic Vitamin В12

Deficiency of Antiscorbutic Vitamin C

Deficiency of Biotin

Deficiency of Rutin

Deficiency of Antixerophthalmic Vitamin A

Deficiency of Antirachitic Vitamin D

Deficiency of Vitamin E

Deficiency of Vitamin F

Deficiency of Antihemorrhagic Vitamin K

Hypervitaminoses

PART THREE. TYPICAL PATHOLOGICAL PROCESSES

Chapter XIV. Pathophysiology of Peripheral Blood Circulation (MD, PhD, DSc, Professor Yuriy V. Byts; MD, PhD, DSc, Professor Anatoliy V. Kubyshkin)

Arterial Hyperemia

Venous Hyperemia

Ischemia

Stasis

Thrombosis

Embolism

Chapter XV. Microcirculatory Disorders (MD, PhD, DSc, Professor Yuriy V. Byts; MD, PhD, DSc, Professor Anatoliy V. Kubyshkin)

Intravascular Mechanisms of Microcirculatory Disorders

Extravascular Mechanisms of Microcirculatory Disorders

Chapter XVI. Inflammation (MD, PhD, DSc, Professor Nikolay V. Krishtal)

Experimental Models of Inflammation

Etiology of Inflammation

Pathogenesis of Inflammation

Alteration

The Inflammatory Cells and Mediators

The Influence of Inflammatory Mediators on the Organism

Vascular Reactions in Inflammation

Exudation

Emigration of the White Blood Cells

Phagocytosis

Proliferation and Regeneration

Classification

Chapter XVII. Pathophysiology of the Immunity (MD, PhD, DSc, Professor Vladislav A. Horban; MD, PhD, DSc, Professor Nikolay V. Krishtal)

The Main Functions and Structure of the Immune System

Genesis and Function of T- and B-Lymphocytes

Experimental Models of Hypofunction of the Immune System

Immune Deficiency Diseases

Immune-Suppressive Diseases

Disorders of the Systems that Functionally Associated with the Immune System

Chapter XVIII. Allergy (MD, PhD, DSc, Professor Vladislav A. Horban)

Etiology

Classification of Allergens

Pathogenesis

Immunological Stage of Allergic Reactions and Their Classification

The Pathochemical Stage of Allergic Reactions

Pathophysiological Stage of Allergic Reactions

Mechanisms of Formation of Allergic Reactions

Autoallergic Diseases

False Allergy (Paraallergy, Heteroallergy)

Prevention of the Allergy. Desensibilization

Chapter XIX. Fever (MD, PhD, DSc, Professor Nikolay N. Zayko)

Etiology

Pathogenesis. The Role of the Thermoregulatory Centers in the Fever Development

Stages of the Fever

Types of Temperature Curves

Difference between Fever and Hyperthermia

Effect of Fever on Body Organs and Systems

Significance of Fever for Organism

Chapter XX. Tumors (Neoplasms) (MD, PhD, DSc, Professor Vladislav A. Horban)

Experimental Models of Neoplasia

Features of the Neoplastic Tissue

Malignancy of Tumors

Etiology of Tumor

Pathogenesis of Tumor

The Tumor Effect on the Organism

The Role of the Organism in the Neoplastic Process

Chapter XXI. Starvation (MD, PhD, DSc, Professor Liudmila Ya. Danilova)

The Complete Starvation

Incomplete Starvation

Partial Starvation

Chapter XXII. Hypoxia (MD, PhD, Associate Professor  Natalia K. Simeonova)

Etiology

Pathogenesis

Compensatory and Adaptive Reactions

Immediate Compensatory Reactions

Delayed Compensatory Reactions

Adaptation

Pathological Changes During the Hypoxia

PART FOUR. PATHOPHYSIOLOGY OF ORGANS AND SYSTEMS

Chapter XXIII. Pathophysiology of the Blood System (MD, PhD, Associate Professor Irina I. Pototskaya)

Total Blood Volume Disorders

Hemorrhage

Pathology of the Erythrocytes

Erythrocytosis

Anemia

The Posthemorrhagic Anemia

Hemolytic Anemia

The Dyserythropoietic Anemia

Pathological Changes of the Leukocytes

Disorders of the Leukopoiesis

Quantitative Changes of the Leukocytes in the Blood

The Qualitative Changes of the Leukocytes in the Blood

Hemoblastosis, Leukemia

Pathology of the Hemostasis

Hemorrhagic Syndromes

Thrombotic Syndromes

Chapter ХХIV. Pathophysiology of Cardiovascular Disorders Caused By Heart Dysfunction (MD, PhD, DSc, Professor Gennadiy M. Butenko)

Heart Failure

Heart Failure Associated with Volume Overload. Mechanisms of Compensation

Heart Failure due to Myocardium Damage

Cardiac Rhythm Disorders

Chapter XXV. Pathophysiology of Cardiovascular Disorders Caused By Vessels Dysfunction (MD, PhD, DSc, Professor Yuriy V. Byts;  MD, PhD, DSc, Professor Nikolay V. Krishtal)

Pathological Changes in the Vessels of the Compensatory Type. Atherosclerosis

Experimental Models of the Atherosclerosis

Etiology

Pathogenesis

Pathophysiology of Vessels of the Resistance (Muscle) Type

Arterial Hypertension

Experimental models of the hypertension

Etiology

Pathogenesis

Pulmonary Hypertension

Arterial Hypotension

Chapter XXVI. Pathophysiology of Extreme States (MD, PhD, Associate Professor Larisa P. Zayarnaya)

Shock

Etiology

Pathogenesis

Specific Features of the Shock Development

Collapse

Chapter XXVII. Pathophysiology of the Respiration (MD, PhD, DSc, Professor Vladimir A. Mikhnev)

Disorders of the Alveolar Ventilation

Disregulative Ventilative Respiratory Insufficiency

Obstructive Ventilative Insufficiency

Restrictive Ventilative Insufficiency

Disorders of the Respiration in the Pulmonary Obstructive and Restrictive Processes

Diffusive Insufficiency of the Lungs

Decrease of the Total Blood Flow in the Lungs

Breaking of the Total and Local Ventilation-Perfusion Ratio in the Lungs

Impact of the Respiratory Failure on the Body

Disorders of Non-Respiratory Functions of the Lungs

Chapter XXVIII. Pathophysiology of the Digestive System (MD, PhD, DSc, Professor Oleg I. Sukmanskiy; MD, PhD, DSc, Professor Vitaliy A. Kostenko)

Appetite Disorder

Digestive Disorders in the Oral Cavity

The Chewing Disorder

Dental Caries

Periodontal Pathology

Disorders of Salivation

Disorders of Swallowing and Esophageal Motility

Digestive Disorders in the Stomach

Disorders of the Stomach Secretion

Disorders of the Stomach Motility

Peptic Ulcer

Intestinal Digestive Disorders

Digestive Disorders Connected with Impairment of the Bile and Pancreatic Juice Secretion

Pancreatitis

Disorders of the Parietal Digestion

Disorder of Intestinal Absorption. Malabsorption Syndrome

Intestinal Motility Disorders

Intestinal Obstruction

Intestinal Dysbiosis. Intestinal Autointoxication

Disorders of Hormone Synthesis in the Digestive System

Chapter XXIX. Pathophysiology of the Liver (MD, PhD, Associate Professor Irina I. Pototskaya)

General Characteristics of Pathological Processes in the Liver

Hepatic Insufficiency

Disorders of the Metabolism in Liver

Hepatic Protective Dysfunctions

Hepatic Coma

Disorders of the Cholopoiesis and Cholekinesis

Disorders of the Hemodynamics at Deseases of Liver

Chapter XXX. Pathophysiology of the Kidneys (MD, PhD, DSc, Professor Nikolay V. Krishtal; MD, PhD, DSc, Professor  Anatoliy I. Gozhenko)

Disorders of the Renal Functions and Processes

Disorders of Glomerular Filtration

Disorders of Tubular Reabsorption and Secretion

Pathogenesis of the Renal Syndromes

Nephrotic Syndrome

Acute Renal Failure

Chronic Renal Failure

Tubulointerstitial Syndrome

Etiology and Pathogenesis of the Main Renal Diseases

Glomerulonephritis

Pyelonephritis

Chapter XXXI. Pathophysiology of the Endocrine System (MD, PhD, DSc, Professor Aleksandr G. Reznikov)

Hormones and Their Role in the Body

Etiology and Pathogenesis of Endocrine Disorders

Dysfunction of the Hypothalamic-Pituitary System

Dysfunctions of the Pituitary

Neuroendocrine Diseases

Disorders of Other Endocrine Organs

Dysfunctions of the Thyroid Gland

Dysfunctions of the Parathyroid Glands

Dysfunctions of the Adrenal Glands

Dysfunctions of the Sex Glands

The Endocrine Dysfunction of the Thymus

Dysfunctions of the Pineal Body (Epiphysis)

Stress and General Adaptation Syndrome

Diabetes Mellitus (MD, PhD, DSc, Professor Nikolay V. Krishtal)

Type 1 Diabetes Mellitus

Type 2 Diabetes Mellitus

Chapter ХХХII. Pathophysiology of the Nervous System (MD, PhD, DSc, Professor Vladimir A. Mikhnev)

Etiology and Pathogenesis of the Nervous System Disorders

Dysfunctions of the Nervous System

Dysfunctions of the Nerve Cells and Conductors

Dysfunctions of the Synapses

Disorders of the Sensitivity

Pain

Disorders of the Motor Functions of the Nervous System

The Nervous Trophicity and Dystrophic Process

Dysfunctions of the Autonomic Nervous System

Experimental Models of Emotional Reactions and their Disorders

Coma (MD, PhD, Associate Professor Larisa P. Zayarnaya)

References

Index