MODULE I
GENERAL PATHOPHYSIOLOGY . . 5
Content module 1. General doctrine of disease, etiology and pathogenesis. Pathogenic effects of environmental factors. Role of internal factors in pathology . . . . 6
Lesson 1. Subject, tasks and methods of pathophysiology . . 6
Lesson 2. General nosology, etiology and pathogenesis . . .. 11
Lesson 3. Pathogenic effects of environmental factors . .. 23
Lesson 4. The role of heredity, constitution and age factors in pathology. Aging . . . . 32
Lesson 5. Reactivity and resistance. Pathophysiology of immunological reactivity . . . . 45
Lesson 6. Allergy . . . 61
Content module 2. Typical pathological processes . . . 78
Lesson 7. Cell Injury . . .. 78
Lesson 8. Peripheral circulatory disorders . . . 94
Lesson 9. Inflammation . . . 104
Lesson 10. Fever . . . 128
Lesson 11. Tumors . . . 137
Content module 3. Typical metabolic disorders . . . . 160
Lesson 12. Impairment of energy metabolism. Starvation . .. 160
Lesson 13. Impairment of carbohydrate metabolism. Diabetes . . . 169
Lesson 14. Impairment of fat and protein metabolism . . 189
Lesson 15. Impairment of water-salt metabolism . . . 200
Lesson 16. Impairment of calcium and phosphate metabolism . . . 215
Lesson 17. Impairment of the acid-base homeostasis . . . 223
MODULE ІІ
PATHOPHYSIOLOGY OF THE ORGANS AND SYSTEMS . 232
Content module 4. Pathophysiology of the blood system . .. 233
Lesson 18. Disorders of the red blood cell system. Posthemorrhagic anemia . . 233
Lesson 19. Hemolytic anemia and anemia due to hematopoietic disorders . . 246
Lesson 20. Leukocytosis and leukopenia . . 267
Lesson 21. Leukemia . . .273
Lesson 22. Hemostasis disorders . . . 283
Content module 5. Pathophysiology of systemic circulation and external respiration . . 301
Lesson 23. Heart failure. Arrhythmias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
Lesson 24. Insufficiency of the coronary circulation. Cardiac ischemia . . . . . . . . 325
Lesson 25. Pathophysiology of blood vessels. Atherosclerosis. Hypertension . . . 336
Lesson 26. Pathophysiology of external respiration . . . . . . . . . . . . . . . . . . . . . . . . . 355
Lesson 27. Hypoxia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 372
Content module 6. Pathophysiology of digestion, liver and kidneys . . . . . . . . . 382
Lesson 28. Digestive disorders in the oral cavity and stomach. Peptic ulcer . . . . 382
Lesson 29. Digestive disorders in the intestines. Acute pancreatitis. Intestinal obstruction . . . 406
Lesson 30. Pathophysiology of liver. Hepatic insufficiency . . . . . . . . . . . . . . . . . . . 415
Lesson 31. Pathophysiology of kidneys. Renal insufficiency . . . . . . . . . . . . . . . . . 433
Content module 7. Pathophysiology of regulatory systems and extreme conditions . . 453
Lesson 32. General pathophysiology of the endocrine system. Adenohypophysis and neurohypophysis disorders . . 453
Lesson 33. Pathophysiology of peripheral endocrine glands . . . . . . . . . . . . . . . . . 467
Lesson 34. Pathophysiology of the nervous system . . . . . . . . . . . . . . . . . . . . . . . . 491
Lesson 35. Pathophysiology of extreme conditions. Shock. Coma . . . . . . . . . . . . 514