Contents
Preface . .. 7
Chapter I. Structure and principles of functioning of the immune system . . 9
1.1. Structure of the immune system . . . 9
1.2. Acquired and congenital immunity . . . 11
1.3. Major histocompatibility complex . . . 19
1.4. Cellular immunity . . . . 21
1.5. Humoral immunity . . .. 34
1.6. Theoretical questions, practical skills and tests for practice and final control . . . . 45
Chapter II. Methods of immunological investigation. The concept of immunogram. Basic rules
for estimation of the immune status . . 49
2.1. Immunologic anamnesis . . . . 49
2.2. Clinical and instrumental methods of estimation of the immune system condition . . . 51
2.3. Syndromes of immune system dysfunction . . . 52
2.4. Laboratory methods of estimation of the immune system . . 53
2.5. Immunogram: indications for administration and interpretation of results . . 59
2.6. Theoretical questions, practical skills and tests for practice and final control . .. 61
Chapter III. Immunity and infectious process. AIDS/HIV . . . . . . . . . . 65
3.1. Characteristics of the course and stages of the infectious process pathogenesis . . . 65
3.2. Antibacterial immunity . . . 66
3.3. Antiviral immunity and protection against multicellular parasites . . . 69
3.4. AIDS/HIV . . . 72
3.5. Criteria of the laboratory estimation of the course of an infectious inflammatory process . . . 76
3.6. Theoretical questions, practical skills and tests
for practical and final control . . 82
Chapter IV. Primary immunodeficiency . 86
4.1. Definition of immunodeficiency . . . 86
4.2. Classification of primary immunodeficiencies . . 86
4.3. Clinical manifestations in the immunodeficient states . . . 91
4.4. Principles of treatment of primary immunodeficiencies . . 93
4.5. Diagnostics and treatment of some primary immunodeficiencies . . . 93
4.6. Theoretical questions, practical skills and self-cotrol tests for practice and final control . . . 99
Chapter V. Acquired (secondary) immunodeficiency . 104
5.1. Definition of the acquired (secondary) immunodeficiency . 104
5.2. Criteria of diagnostics of secondary immunodeficiency conditions . . . 105
5.3. Basic principles of immunotropic therapy prescription. Immunorehabilitation and immunoprophylaxis . . 107
5.4. Systematization of immunotropic therapy and groups of immunotropic preparations in Ukraine . . . 109
5.5. General recommendations for immunotropic therapy prescription . . . 111
5.6. Theoretical questions, practical skills and self-cotrol tests for practice and final control . .114
Chapter VI. Fundamentals of transplantation immunity . 118
6.1. The concept of transplantation immunity . .118
6.2. Types of transplants (grafts) . . . 118
6.3. Forms and mechanisms of the transplant rejection . .119
6.4. Pre-transplantation monitoring . . . . 122
6.5. Immunosuppressive therapy and posttransplantation monitoring . . 125
6.6. Theoretical questions, practical skills and tests for practice and final control . .127
Chapter VII. Reproductive immunology . . . 131
7.1. Immune interrelations in the system “father – mother – fetus” . 131
7.2. Miscarriage (noncarrying of pregnancy) . 133
7.3. Immunodependent forms of infertility in marriage .37
7.4. Immune aspects of contraception . . 140
7.5. Diagnostics of reproduction immunopathology .141
7.6. Theoretical questions, practical skills and tests for practice and final control . . 142
Chapter VIII. Antineoplastic іmmunіty . . 147
8.1. Classification of oncogenes. Causes of tumors . .147
8.2. Antineoplastic protection . .48
8.3. Factors of immune resistance of tumor cells . .151
8.4. Antigens of superficial structures of tumor cells . . 153
8.5. Immunodiagnostics and immunotherapy of tumors . 154
8.6. Theoretical questions, practical skills and tests for practice and final control . .165
Chapter IX. Autoimmune diseases . 168
9.1. The concept of autoimmunity reaction and autoimmune disease . 168
9.2. Etiology a